Expression of KCNJ3 in cancer - Summary - The Human Protein Atlas

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KCNJ3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNJ3
Gene description	Potassium channel, inwardly rectifying subfamily J, member 3
Protein class	Plasma proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, renal cancer)
HPA (cell line):	Cell line enhanced (BJ)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA024231
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024231

GENE INFORMATION
Gene name	KCNJ3 (HGNC Symbol)
Synonyms	GIRK1, KGA, Kir3.1
Description	Potassium channel, inwardly rectifying subfamily J, member 3 (HGNC Symbol)
Entrez gene summary	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]
Chromosome	2
Cytoband	q24.1
Chromosome location (bp)	154698299 - 154858352
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162989 (version 83.38)
Entrez gene	3760
UniProt	P48549 (UniProt - Evidence at protein level)
neXtProt	NX_P48549
Antibodypedia	KCNJ3 antibodies

PROTEIN BROWSER

KCNJ3-001	KCNJ3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ3-001 ENSP00000295101 ENST00000295101	P48549 [Direct mapping] G protein-activated inward rectifier potassium channel 1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010107 [potassium ion import] GO:0015467 [G-protein activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0030315 [T-tubule] GO:0034765 [regulation of ion transmembrane transport] GO:0051602 [response to electrical stimulus] Show all	501 aa 56.6 kDa	No	2
KCNJ3-201 ENSP00000438410 ENST00000544049	P48549 [Direct mapping] G protein-activated inward rectifier potassium channel 1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0015467 [G-protein activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	235 aa 26.8 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.