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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MSX1
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MSX1

Gene description

Msh homeobox 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (endometrial cancer)
HPA (cell line):Cell line enhanced (CACO-2)
HPA (normal tissue):Group enriched (cervix, uterine, endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct nuclear expression in the uterine tract and endometrial glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA073604 , CAB026198
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA073604
CAB026198

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong nuclear staining was observed in endometrial cancers and a few prostate cancers showed cytoplasmic positivity. Other cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were essentially negative.

GENE INFORMATION

Gene name

MSX1 (HGNC Symbol)

Synonyms

HOX7, HYD1, OFC5

Description

Msh homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p16.2

Chromosome location (bp)

4859666 - 4863936

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163132 (version 83.38)

Entrez gene

4487

UniProt

P28360 (UniProt - Evidence at protein level)

neXtProt

NX_P28360

Antibodypedia

MSX1 antibodies

PROTEIN BROWSER

MSX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSX1-001
ENSP00000372170
ENST00000382723
P28360 [Direct mapping]
Homeobox protein MSX-1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002039 [p53 binding]
GO:0003007 [heart morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009952 [anterior/posterior pattern specification]
GO:0010463 [mesenchymal cell proliferation]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030308 [negative regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0034504 [protein localization to nucleus]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035880 [embryonic nail plate morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042476 [odontogenesis]
GO:0042481 [regulation of odontogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048863 [stem cell differentiation]
GO:0050821 [protein stabilization]
GO:0051154 [negative regulation of striated muscle cell differentiation]
GO:0060021 [palate development]
GO:0060325 [face morphogenesis]
GO:0060349 [bone morphogenesis]
GO:0060536 [cartilage morphogenesis]
GO:0061180 [mammary gland epithelium development]
GO:0061312 [BMP signaling pathway involved in heart development]
GO:0090427 [activation of meiosis]
GO:1902255 [positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
GO:2001055 [positive regulation of mesenchymal cell apoptotic process]
Show all
303 aa
31.5 kDa
No 0

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