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DHX57

GENERAL INFORMATION

Gene name

 DHX57

Gene description

 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA036160
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036160

GENE INFORMATION

Gene name

 DHX57 (HGNC Symbol)

Synonyms

 DDX57

Description

 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p22.1

Chromosome location (bp)

 38797729 - 38875934

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163214 (version 83.38)

Entrez gene

 90957

UniProt

 Q6P158 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P158

Antibodypedia

 DHX57 antibodies

PROTEIN BROWSER
DHX57-001
DHX57-005
DHX57-010
DHX57-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX57-001
ENSP00000405111
ENST00000457308
Q6P158 [Direct mapping]
Putative ATP-dependent RNA helicase DHX57
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006396 [RNA processing]
GO:0008026 [ATP-dependent helicase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 1386 aa
155.6 kDa 		No 0
DHX57-005
ENSP00000479840
ENST00000619207
A0A087WW12 [Direct mapping]
Putative ATP-dependent RNA helicase DHX57
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006396 [RNA processing]
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 106 aa
11.8 kDa 		No 0
DHX57-010
ENSP00000397841
ENST00000452978
H7C109 [Direct mapping]
Putative ATP-dependent RNA helicase DHX57
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006396 [RNA processing]
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 665 aa
74.9 kDa 		No 0
DHX57-011
ENSP00000387404
ENST00000442331
H7BZ23 [Direct mapping]
Putative ATP-dependent RNA helicase DHX57
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006396 [RNA processing]
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 51 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.