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PGLYRP4

GENERAL INFORMATION

Gene name

 PGLYRP4

Gene description

 Peptidoglycan recognition protein 4

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, lung cancer, melanoma, urothelial cancer)
HPA (cell line):Cell line enhanced (HaCaT, HDLM-2, Karpas-707)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, lung cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PGLYRP4 (HGNC Symbol)

Synonyms

 PGLYRPIbeta, PGRP-Ibeta, PGRPIB, SBBI67

Description

 Peptidoglycan recognition protein 4 (HGNC Symbol)

Entrez gene summary

 Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153330120 - 153348840

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163218 (version 83.38)

Entrez gene

 57115

UniProt

 Q96LB8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96LB8

Antibodypedia

 PGLYRP4 antibodies

PROTEIN BROWSER
PGLYRP4-001
PGLYRP4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGLYRP4-001
ENSP00000352672
ENST00000359650
Q96LB8 [Direct mapping]
Peptidoglycan recognition protein 4
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity]
GO:0009253 [peptidoglycan catabolic process]
GO:0016019 [peptidoglycan receptor activity]
GO:0016020 [membrane]
GO:0016045 [detection of bacterium]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032827 [negative regulation of natural killer cell differentiation involved in immune response]
GO:0042834 [peptidoglycan binding]
GO:0044117 [growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0050830 [defense response to Gram-positive bacterium]
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 373 aa
40.6 kDa 		Yes 0
PGLYRP4-002
ENSP00000357728
ENST00000368739
Q96LB8 [Direct mapping]
Peptidoglycan recognition protein 4
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity]
GO:0009253 [peptidoglycan catabolic process]
GO:0016019 [peptidoglycan receptor activity]
GO:0016020 [membrane]
GO:0016045 [detection of bacterium]
GO:0042834 [peptidoglycan binding]
GO:0045087 [innate immune response]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 369 aa
40.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.