Fields »
ABOUT
HELP
BLOG
S100A12

GENERAL INFORMATION

Gene name

 S100A12

Gene description

 S100 calcium binding protein A12

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
GTEx:Group enriched (lung, spleen)
FANTOM5:Tissue enhanced (heart muscle, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in lymphoid organs and peripheral immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002881 , CAB025872
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, spleen)

GENE INFORMATION

Gene name

 S100A12 (HGNC Symbol)

Synonyms

 CAAF1, CAGC, CGRP, ENRAGE, MRP6, p6

Description

 S100 calcium binding protein A12 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153373706 - 153375649

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163221 (version 83.38)

Entrez gene

 6283

UniProt

 P80511 (UniProt - Evidence at protein level)

neXtProt

 NX_P80511

Antibodypedia

 S100A12 antibodies

PROTEIN BROWSER
S100A12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
S100A12-001
ENSP00000357726
ENST00000368737
P80511 [Direct mapping]
Protein S100-A12 Calcitermin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0008270 [zinc ion binding]
GO:0030593 [neutrophil chemotaxis]
GO:0031640 [killing of cells of other organism]
GO:0042742 [defense response to bacterium]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045576 [mast cell activation]
GO:0050663 [cytokine secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0050786 [RAGE receptor binding]
GO:0050832 [defense response to fungus]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 92 aa
10.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.