Fields »
ABOUT
HELP
BLOG
ALPP

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 ALPP

Gene description

 Alkaline phosphatase, placental

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Group enriched (HaCaT, SiHa)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA038764
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HaCaT, SiHa)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038764 HeLa Plasma membrane
HPA038764 SiHa No staining    
HPA038764 U-2 OS No staining    

GENE INFORMATION

Gene name

 ALPP

Synonyms

Description

 Alkaline phosphatase, placental (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 232378534 - 232382889

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163283 (version 83.38)

Entrez gene

 250

UniProt

 P05187 (UniProt - Evidence at protein level)

neXtProt

 NX_P05187

Antibodypedia

 ALPP antibodies

PROTEIN BROWSER
ALPP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALPP-001
ENSP00000375881
ENST00000392027
P05187 [Direct mapping]
Alkaline phosphatase, placental type
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
Show all
 535 aa
58 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.