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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ALPP
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  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ALPP

Gene description

Alkaline phosphatase, placental

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Group enriched (HaCaT, SiHa)
HPA (normal tissue):Group enriched (cervix, uterine, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 4 antibodies.
HPA038764 , HPA038765 , HPA051699 , CAB026327
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PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY

HPA038764
HPA038765
HPA051699
CAB026327

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Distinct cytoplasmic and membranous staining was observed in testicular cancers as well as cases of endometrial cancers. Fractions of cells in cases of ovarian, cervical and gastric cancers exhibited moderate to strong cytoplasmic and membranous staining. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of hepatocellular carcinomas and endometrial cancers along with a case of gastric cancer displayed strong cytoplasmic positivity. A few testicular cancers showed moderate cytoplasmic and membranous staining. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of seminomas, endometrial and ovarian cancers displayed moderate to strong luminal membranous and cytoplasmic immunoreactivity. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Ovarian serous cancers, testis and endometrial cancers displayed moderate to strong cytoplasmic and membranous staining. Remaining cancers were negative.

GENE INFORMATION

Gene name

ALPP

Synonyms

Description

Alkaline phosphatase, placental (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

232378534 - 232382889

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163283 (version 83.38)

Entrez gene

250

UniProt

P05187 (UniProt - Evidence at protein level)

neXtProt

NX_P05187

Antibodypedia

ALPP antibodies

PROTEIN BROWSER

ALPP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALPP-001
ENSP00000375881
ENST00000392027
P05187 [Direct mapping]
Alkaline phosphatase, placental type
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
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535 aa
58 kDa
Yes 0

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