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ALPP

GENERAL INFORMATION

Gene name

 ALPP

Gene description

 Alkaline phosphatase, placental

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Group enriched (HaCaT, SiHa)
HPA (normal tissue):Group enriched (cervix, uterine, placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA038764 , HPA038765 , HPA051699 , CAB026327
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA038764
HPA038765
HPA051699
CAB026327

GENE INFORMATION

Gene name

 ALPP

Synonyms

Description

 Alkaline phosphatase, placental (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 232378534 - 232382889

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163283 (version 83.38)

Entrez gene

 250

UniProt

 P05187 (UniProt - Evidence at protein level)

neXtProt

 NX_P05187

Antibodypedia

 ALPP antibodies

PROTEIN BROWSER
ALPP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALPP-001
ENSP00000375881
ENST00000392027
P05187 [Direct mapping]
Alkaline phosphatase, placental type
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
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 535 aa
58 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.