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MRPS18C

GENERAL INFORMATION

Gene name

 MRPS18C

Gene description

 Mitochondrial ribosomal protein S18C

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA050404
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050404

GENE INFORMATION

Gene name

 MRPS18C (HGNC Symbol)

Synonyms

 CGI-134, FLJ11146, FLJ22967, MRPS18-1

Description

 Mitochondrial ribosomal protein S18C (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q21.23

Chromosome location (bp)

 83455932 - 83469735

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163319 (version 83.38)

Entrez gene

 51023

UniProt

 Q9Y3D5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3D5

Antibodypedia

 MRPS18C antibodies

PROTEIN BROWSER
MRPS18C-001
MRPS18C-003
MRPS18C-005
MRPS18C-006
MRPS18C-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS18C-001
ENSP00000295491
ENST00000295491
Q9Y3D5 [Direct mapping]
28S ribosomal protein S18c, mitochondrial
A0A024RDH9 [Target identity:100%; Query identity:100%]
Mitochondrial ribosomal protein S18C, isoform CRA_b
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 142 aa
15.8 kDa 		No 0
MRPS18C-003
ENSP00000427169
ENST00000507019
D6RCM2 [Direct mapping]
28S ribosomal protein S18c, mitochondrial; Mitochondrial ribosomal protein S18C, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 114 aa
12.6 kDa 		No 0
MRPS18C-005
ENSP00000425268
ENST00000505719
H0Y9W2 [Direct mapping]
28S ribosomal protein S18c, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 92 aa
10.3 kDa 		No 0
MRPS18C-006
ENSP00000426930
ENST00000507349
D6RE70 [Direct mapping]
28S ribosomal protein S18c, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0006412 [translation]
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 68 aa
7.5 kDa 		No 0
MRPS18C-010
ENSP00000427014
ENST00000509970
H0YAG5 [Direct mapping]
28S ribosomal protein S18c, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 113 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.