Fields »
ABOUT
HELP
BLOG
CLDN1

GENERAL INFORMATION

Gene name

 CLDN1

Gene description

 Claudin 1

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (EFO-21, HaCaT, hTCEpi, RPTEC TERT1, RT4)
HPA (normal tissue):Tissue enhanced (skin, smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in several tissues, most abundant in squamous epithelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA048319 , CAB002602
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048319
CAB002602

GENE INFORMATION

Gene name

 CLDN1 (HGNC Symbol)

Synonyms

 ILVASC, SEMP1

Description

 Claudin 1 (HGNC Symbol)

Entrez gene summary

 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q28

Chromosome location (bp)

 190305701 - 190322475

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163347 (version 83.38)

Entrez gene

 9076

UniProt

 O95832 (UniProt - Evidence at protein level)

neXtProt

 NX_O95832

Antibodypedia

 CLDN1 antibodies

PROTEIN BROWSER
CLDN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLDN1-001
ENSP00000295522
ENST00000295522
O95832 [Direct mapping]
Claudin-1
A5JSJ9 [Target identity:100%; Query identity:100%]
Claudin
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0030054 [cell junction]
GO:0042802 [identical protein binding]
GO:0045216 [cell-cell junction organization]
GO:0046718 [viral entry into host cell]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0061436 [establishment of skin barrier]
GO:0070830 [bicellular tight junction assembly]
Show all
 211 aa
22.7 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.