Expression of HIPK1 in cancer - Summary - The Human Protein Atlas

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HIPK1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HIPK1
Gene description	Homeodomain interacting protein kinase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear exprssion in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA016664
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016664

GENE INFORMATION
Gene name	HIPK1 (HGNC Symbol)
Synonyms	KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2
Description	Homeodomain interacting protein kinase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	113929192 - 113977869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163349 (version 83.38)
Entrez gene	204851
UniProt	Q86Z02 (UniProt - Evidence at protein level)
neXtProt	NX_Q86Z02
Antibodypedia	HIPK1 antibodies

PROTEIN BROWSER

HIPK1-001	HIPK1-002	HIPK1-003	HIPK1-004	HIPK1-006	HIPK1-007	HIPK1-008	HIPK1-009	HIPK1-010	HIPK1-011	HIPK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIPK1-001 ENSP00000358571 ENST00000369558	Q86Z02 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0009952 [anterior/posterior pattern specification] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0010842 [retina layer formation] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0030182 [neuron differentiation] GO:0034333 [adherens junction assembly] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0045766 [positive regulation of angiogenesis] GO:0048596 [embryonic camera-type eye morphogenesis] GO:0060059 [embryonic retina morphogenesis in camera-type eye] GO:0060216 [definitive hemopoiesis] GO:0060235 [lens induction in camera-type eye] GO:0061072 [iris morphogenesis] GO:0072577 [endothelial cell apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	1210 aa 130.8 kDa	No	1
HIPK1-002 ENSP00000358572 ENST00000369559	Q86Z02 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0045766 [positive regulation of angiogenesis] GO:0060216 [definitive hemopoiesis] GO:0072577 [endothelial cell apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	1075 aa 116.7 kDa	No	1
HIPK1-003 ENSP00000355191 ENST00000361587	H3BLW0 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		491 aa 51.3 kDa	No	0
HIPK1-004 ENSP00000358568 ENST00000369555	Q5SQL3 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1165 aa 126.3 kDa	No	1
HIPK1-006 ENSP00000407442 ENST00000426820	Q86Z02 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0045766 [positive regulation of angiogenesis] GO:0060216 [definitive hemopoiesis] GO:0072577 [endothelial cell apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	1210 aa 130.8 kDa	No	1
HIPK1-007 ENSP00000340956 ENST00000340480	Q86Z02 [Direct mapping] Homeodomain-interacting protein kinase 1 A0A024R0H9 [Target identity:100%; Query identity:100%] Homeodomain interacting protein kinase 1, isoform CRA_f Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SignalP predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0045766 [positive regulation of angiogenesis] GO:0060216 [definitive hemopoiesis] GO:0072577 [endothelial cell apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	836 aa 89.5 kDa	No	0
HIPK1-008 ENSP00000358566 ENST00000369553	Q86Z02 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0045766 [positive regulation of angiogenesis] GO:0060216 [definitive hemopoiesis] GO:0072577 [endothelial cell apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	816 aa 87.3 kDa	No	0
HIPK1-009 ENSP00000358574 ENST00000369561	J3KP92 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1176 aa 127.1 kDa	No	1
HIPK1-010 ENSP00000422322 ENST00000514621	D6RC95 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 12.6 kDa	No	0
HIPK1-011 ENSP00000426695 ENST00000503968	D6RF28 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.1 kDa	No	0
HIPK1-201 ENSP00000486090 ENST00000626993	Q5SQL3 [Direct mapping] Homeodomain-interacting protein kinase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1165 aa 126.3 kDa	No	1

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The Human Protein Atlas

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