Expression of TRIM46 in cancer - Summary - The Human Protein Atlas

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TRIM46

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRIM46
Gene description	Tripartite motif containing 46
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030389
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030389

GENE INFORMATION
Gene name	TRIM46 (HGNC Symbol)
Synonyms	FLJ23229, TRIFIC
Description	Tripartite motif containing 46 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155173787 - 155184971
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163462 (version 83.38)
Entrez gene	80128
UniProt	Q7Z4K8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z4K8
Antibodypedia	TRIM46 antibodies

PROTEIN BROWSER

TRIM46-001	TRIM46-002	TRIM46-003	TRIM46-004	TRIM46-201	TRIM46-202	TRIM46-203	TRIM46-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM46-001 ENSP00000334657 ENST00000334634	Q7Z4K8 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	759 aa 83.4 kDa	No	0
TRIM46-002 ENSP00000357366 ENST00000368382	Q7Z4K8 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	736 aa 80.9 kDa	No	0
TRIM46-003 ENSP00000357369 ENST00000368385	Q7Z4K8 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	551 aa 61.8 kDa	No	0
TRIM46-004 ENSP00000357367 ENST00000368383	Q5VT61 [Direct mapping] Tripartite motif-containing 46, isoform CRA_c; Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	644 aa 71.8 kDa	No	0
TRIM46-201 ENSP00000376245 ENST00000392451	A0A0A0MS35 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	717 aa 78.8 kDa	No	0
TRIM46-202 ENSP00000442719 ENST00000543729	Q7Z4K8 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	498 aa 54.8 kDa	No	0
TRIM46-203 ENSP00000440254 ENST00000545012	F5GYK0 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	633 aa 69.6 kDa	No	0
TRIM46-204 ENSP00000478669 ENST00000611379	A0A087WUH1 [Direct mapping] Tripartite motif-containing protein 46 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	746 aa 81.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.