Expression of STK36 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

STK36

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STK36
Gene description	Serine/threonine kinase 36
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA027409 , HPA027453 , HPA030058
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027409	HPA027453	HPA030058

GENE INFORMATION
Gene name	STK36 (HGNC Symbol)
Synonyms	FU, KIAA1278
Description	Serine/threonine kinase 36 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218672026 - 218702716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163482 (version 83.38)
Entrez gene	27148
UniProt	Q9NRP7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRP7
Antibodypedia	STK36 antibodies

PROTEIN BROWSER

STK36-001	STK36-002	STK36-003	STK36-006	STK36-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STK36-001 ENSP00000295709 ENST00000295709	Q9NRP7 [Direct mapping] Serine/threonine-protein kinase 36 Show all	Enzymes ENZYME proteins Transferases Kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003351 [epithelial cilium movement] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007228 [positive regulation of hh target transcription factor activity] GO:0007420 [brain development] GO:0008134 [transcription factor binding] GO:0009791 [post-embryonic development] GO:0042384 [cilium assembly] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] Show all	1315 aa 144 kDa	No	2
STK36-002 ENSP00000375954 ENST00000392105	Q9NRP7 [Direct mapping] Serine/threonine-protein kinase 36 Show all	Enzymes ENZYME proteins Transferases Kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007228 [positive regulation of hh target transcription factor activity] GO:0008134 [transcription factor binding] GO:0009791 [post-embryonic development] GO:0042384 [cilium assembly] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] Show all	1294 aa 141.7 kDa	No	1
STK36-003 ENSP00000394095 ENST00000440309	Q9NRP7 [Direct mapping] Serine/threonine-protein kinase 36 Show all	Enzymes ENZYME proteins Transferases Kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007228 [positive regulation of hh target transcription factor activity] GO:0008134 [transcription factor binding] GO:0009791 [post-embryonic development] GO:0042384 [cilium assembly] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] Show all	1315 aa 144 kDa	No	2
STK36-006 ENSP00000400055 ENST00000455724	C9J1B8 [Direct mapping] Serine/threonine-protein kinase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	75 aa 8.7 kDa	No	0
STK36-009 ENSP00000403527 ENST00000424080	C9JDA4 [Direct mapping] Serine/threonine-protein kinase 36 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	279 aa 31.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.