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STK36

GENERAL INFORMATION

Gene name

 STK36

Gene description

 Serine/threonine kinase 36

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA027409 , HPA027453 , HPA030058
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 STK36 (HGNC Symbol)

Synonyms

 FU, KIAA1278

Description

 Serine/threonine kinase 36 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218672026 - 218702716

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163482 (version 83.38)

Entrez gene

 27148

UniProt

 Q9NRP7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRP7

Antibodypedia

 STK36 antibodies

PROTEIN BROWSER
STK36-001
STK36-002
STK36-003
STK36-006
STK36-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STK36-001
ENSP00000295709
ENST00000295709
Q9NRP7 [Direct mapping]
Serine/threonine-protein kinase 36
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003351 [epithelial cilium movement]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007228 [positive regulation of hh target transcription factor activity]
GO:0007420 [brain development]
GO:0008134 [transcription factor binding]
GO:0009791 [post-embryonic development]
GO:0042384 [cilium assembly]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1315 aa
144 kDa 		No 2
STK36-002
ENSP00000375954
ENST00000392105
Q9NRP7 [Direct mapping]
Serine/threonine-protein kinase 36
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007228 [positive regulation of hh target transcription factor activity]
GO:0008134 [transcription factor binding]
GO:0009791 [post-embryonic development]
GO:0042384 [cilium assembly]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1294 aa
141.7 kDa 		No 1
STK36-003
ENSP00000394095
ENST00000440309
Q9NRP7 [Direct mapping]
Serine/threonine-protein kinase 36
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007228 [positive regulation of hh target transcription factor activity]
GO:0008134 [transcription factor binding]
GO:0009791 [post-embryonic development]
GO:0042384 [cilium assembly]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
Show all
 1315 aa
144 kDa 		No 2
STK36-006
ENSP00000400055
ENST00000455724
C9J1B8 [Direct mapping]
Serine/threonine-protein kinase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 75 aa
8.7 kDa 		No 0
STK36-009
ENSP00000403527
ENST00000424080
C9JDA4 [Direct mapping]
Serine/threonine-protein kinase 36
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 279 aa
31.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.