Cell line enhanced (CACO-2, RH-30, RPTEC TERT1, SK-BR-3)
HPA (normal tissue):
Tissue enhanced (cerebral cortex, testis)
Evidence at protein level
ANTIBODY IHC RELIABILITY
Pending cancer tissue analysis.
Gene product is not prognostic.
RNA EXPRESSION OVERVIEW
RNA cancer category: Tissue enhanced (glioma)
Pending cancer tissue analysis
ADORA1 (HGNC Symbol)
Adenosine A1 receptor (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]