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Gene name

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ADORA1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADORA1

Gene description

Adenosine A1 receptor

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex, testis)
GTEx:Mixed
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

ADORA1 (HGNC Symbol)

Synonyms

RDC7

Description

Adenosine A1 receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

203090654 - 203167405

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163485 (version 83.38)

Entrez gene

134

UniProt

P30542 (UniProt - Evidence at protein level)

neXtProt

NX_P30542

Antibodypedia

ADORA1 antibodies

PROTEIN BROWSER

ADORA1-001
ADORA1-002
ADORA1-003
ADORA1-201
ADORA1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADORA1-001
ENSP00000356205
ENST00000367236
P30542 [Direct mapping]
Adenosine receptor A1
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001659 [temperature homeostasis]
GO:0001664 [G-protein coupled receptor binding]
GO:0001666 [response to hypoxia]
GO:0001883 [purine nucleoside binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0002087 [regulation of respiratory gaseous exchange by neurological system process]
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002686 [negative regulation of leukocyte migration]
GO:0002793 [positive regulation of peptide secretion]
GO:0003093 [regulation of glomerular filtration]
GO:0004629 [phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006612 [protein targeting to membrane]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0008285 [negative regulation of cell proliferation]
GO:0012505 [endomembrane system]
GO:0014050 [negative regulation of glutamate secretion]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0016042 [lipid catabolic process]
GO:0016323 [basolateral plasma membrane]
GO:0030425 [dendrite]
GO:0030673 [axolemma]
GO:0031072 [heat shock protein binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0032229 [negative regulation of synaptic transmission, GABAergic]
GO:0032244 [positive regulation of nucleoside transport]
GO:0032279 [asymmetric synapse]
GO:0032795 [heterotrimeric G-protein binding]
GO:0032900 [negative regulation of neurotrophin production]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035814 [negative regulation of renal sodium excretion]
GO:0042321 [negative regulation of circadian sleep/wake cycle, sleep]
GO:0042323 [negative regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044297 [cell body]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0045822 [negative regulation of heart contraction]
GO:0045908 [negative regulation of vasodilation]
GO:0046888 [negative regulation of hormone secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048786 [presynaptic active zone]
GO:0050728 [negative regulation of inflammatory response]
GO:0050890 [cognition]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0051930 [regulation of sensory perception of pain]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0055118 [negative regulation of cardiac muscle contraction]
GO:0060079 [excitatory postsynaptic potential]
GO:0060087 [relaxation of vascular smooth muscle]
GO:0070256 [negative regulation of mucus secretion]
GO:0097190 [apoptotic signaling pathway]
GO:1900453 [negative regulation of long term synaptic depression]
Show all
326 aa
36.5 kDa
No 7
ADORA1-002
ENSP00000308549
ENST00000309502
P30542 [Direct mapping]
Adenosine receptor A1
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0016021 [integral component of membrane]
GO:0097190 [apoptotic signaling pathway]
Show all
326 aa
36.5 kDa
No 7
ADORA1-003
ENSP00000356204
ENST00000367235
P30542 [Direct mapping]
Adenosine receptor A1
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0016021 [integral component of membrane]
GO:0097190 [apoptotic signaling pathway]
Show all
125 aa
13.3 kDa
No 3
ADORA1-201
ENSP00000338435
ENST00000337894
P30542 [Direct mapping]
Adenosine receptor A1
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0016021 [integral component of membrane]
GO:0097190 [apoptotic signaling pathway]
Show all
326 aa
36.5 kDa
No 7
ADORA1-202
ENSP00000483953
ENST00000618295
A0A087X173 [Direct mapping]
Adenosine receptor A1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
210 aa
24.1 kDa
No 3

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