Expression of FCRL1 in cancer - Summary - The Human Protein Atlas

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FCRL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FCRL1
Gene description	Fc receptor-like 1
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (Daudi, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells and lymphoid tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA013323
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013323

GENE INFORMATION
Gene name	FCRL1 (HGNC Symbol)
Synonyms	CD307a, FCRH1, IFGP1, IRTA5
Description	Fc receptor-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	157794403 - 157820105
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163534 (version 83.38)
Entrez gene	115350
UniProt	Q96LA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96LA6
Antibodypedia	FCRL1 antibodies

PROTEIN BROWSER

FCRL1-001	FCRL1-002	FCRL1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCRL1-001 ENSP00000357158 ENST00000368176	Q96LA6 [Direct mapping] Fc receptor-like protein 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	429 aa 46.9 kDa	Yes	1
FCRL1-002 ENSP00000351039 ENST00000358292	Q96LA6 [Direct mapping] Fc receptor-like protein 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	366 aa 40.4 kDa	Yes	0
FCRL1-003 ENSP00000418130 ENST00000491942	Q96LA6 [Direct mapping] Fc receptor-like protein 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	428 aa 46.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.