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FCRL1

GENERAL INFORMATION

Gene name

 FCRL1

Gene description

 Fc receptor-like 1

Protein class

 CD markers
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen, tonsil)
GTEx:Group enriched (small intestine, spleen)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells and lymphoid tissue.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA013323
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 FCRL1 (HGNC Symbol)

Synonyms

 CD307a, FCRH1, IFGP1, IRTA5

Description

 Fc receptor-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 157794403 - 157820105

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163534 (version 83.38)

Entrez gene

 115350

UniProt

 Q96LA6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96LA6

Antibodypedia

 FCRL1 antibodies

PROTEIN BROWSER
FCRL1-001
FCRL1-002
FCRL1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FCRL1-001
ENSP00000357158
ENST00000368176
Q96LA6 [Direct mapping]
Fc receptor-like protein 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
Show all
 429 aa
46.9 kDa 		Yes 1
FCRL1-002
ENSP00000351039
ENST00000358292
Q96LA6 [Direct mapping]
Fc receptor-like protein 1
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
Show all
 366 aa
40.4 kDa 		Yes 0
FCRL1-003
ENSP00000418130
ENST00000491942
Q96LA6 [Direct mapping]
Fc receptor-like protein 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
Show all
 428 aa
46.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.