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SUCLG1

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GENERAL INFORMATION

Gene name

 SUCLG1

Gene description

 Succinate-CoA ligase, alpha subunit

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Additional location

 In addition localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA036683
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the plasma membrane.

Main location

 Mitochondria (supported)

Additional location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA036683 A-431 Plasma membrane
Mitochondria
HPA036683 U-2 OS Plasma membrane
Mitochondria
Cytosol
HPA036683 U-251 MG Plasma membrane
Mitochondria

GENE INFORMATION

Gene name

 SUCLG1

Synonyms

Description

 Succinate-CoA ligase, alpha subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 84423523 - 84460045

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163541 (version 83.38)

Entrez gene

 8802

UniProt

 P53597 (UniProt - Evidence at protein level)

neXtProt

 NX_P53597

Antibodypedia

 SUCLG1 antibodies

PROTEIN BROWSER
SUCLG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUCLG1-001
ENSP00000377446
ENST00000393868
P53597 [Direct mapping]
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004775 [succinate-CoA ligase (ADP-forming) activity]
GO:0004776 [succinate-CoA ligase (GDP-forming) activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0006104 [succinyl-CoA metabolic process]
GO:0006105 [succinate metabolic process]
GO:0008152 [metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
 346 aa
36.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.