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SUCLG1

GENERAL INFORMATION

Gene name

 SUCLG1

Gene description

 Succinate-CoA ligase, alpha subunit

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036683 , HPA036684
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036683
HPA036684

GENE INFORMATION

Gene name

 SUCLG1

Synonyms

Description

 Succinate-CoA ligase, alpha subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 84423523 - 84460045

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163541 (version 83.38)

Entrez gene

 8802

UniProt

 P53597 (UniProt - Evidence at protein level)

neXtProt

 NX_P53597

Antibodypedia

 SUCLG1 antibodies

PROTEIN BROWSER
SUCLG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUCLG1-001
ENSP00000377446
ENST00000393868
P53597 [Direct mapping]
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004775 [succinate-CoA ligase (ADP-forming) activity]
GO:0004776 [succinate-CoA ligase (GDP-forming) activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0006104 [succinyl-CoA metabolic process]
GO:0006105 [succinate metabolic process]
GO:0008152 [metabolic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
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 346 aa
36.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.