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Gene name

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Reliability

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SPTA1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SPTA1

Gene description

Spectrin, alpha, erythrocytic 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Group enriched (spleen, testis)
FANTOM5:Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in bone marrow and distinct positivity in erythrocytes.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 4 antibodies.
HPA028048 , HPA028253 , CAB016193 , CAB037246
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION

Gene name

SPTA1 (HGNC Symbol)

Synonyms

EL2

Description

Spectrin, alpha, erythrocytic 1 (HGNC Symbol)

Entrez gene summary

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.1

Chromosome location (bp)

158610706 - 158686698

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163554 (version 83.38)

Entrez gene

6708

UniProt

P02549 (UniProt - Evidence at protein level)

neXtProt

NX_P02549

Antibodypedia

SPTA1 antibodies

PROTEIN BROWSER

SPTA1-001
SPTA1-003
SPTA1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPTA1-001
ENSP00000357129
ENST00000368147
P02549 [Direct mapping]
Spectrin alpha chain, erythrocytic 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002260 [lymphocyte homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006779 [porphyrin-containing compound biosynthetic process]
GO:0007009 [plasma membrane organization]
GO:0007015 [actin filament organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008091 [spectrin]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030097 [hemopoiesis]
GO:0030863 [cortical cytoskeleton]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032437 [cuticular plate]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051693 [actin filament capping]
Show all
2419 aa
280 kDa
No 0
SPTA1-003
ENSP00000476485
ENST00000467387
V9GY79 [Direct mapping]
Spectrin alpha chain, erythrocytic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
124 aa
14.4 kDa
No 0
SPTA1-201
ENSP00000482595
ENST00000614909
A0A087WZE4 [Direct mapping]
Spectrin alpha chain, erythrocytic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
2430 aa
281.1 kDa
No 0

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