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PRKCI

GENERAL INFORMATION

Gene name

 PRKCI

Gene description

 Protein kinase C, iota

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA026574
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRKCI (HGNC Symbol)

Synonyms

 DXS1179E, PKCI

Description

 Protein kinase C, iota (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q26.2

Chromosome location (bp)

 170222365 - 170305981

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163558 (version 83.38)

Entrez gene

 5584

UniProt

 P41743 (UniProt - Evidence at protein level)

neXtProt

 NX_P41743

Antibodypedia

 PRKCI antibodies

PROTEIN BROWSER
PRKCI-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKCI-001
ENSP00000295797
ENST00000295797
P41743 [Direct mapping]
Protein kinase C iota type
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006468 [protein phosphorylation]
GO:0006612 [protein targeting to membrane]
GO:0007010 [cytoskeleton organization]
GO:0007015 [actin filament organization]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016192 [vesicle-mediated transport]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0019904 [protein domain specific binding]
GO:0031252 [cell leading edge]
GO:0032869 [cellular response to insulin stimulus]
GO:0034329 [cell junction assembly]
GO:0034351 [negative regulation of glial cell apoptotic process]
GO:0034613 [cellular protein localization]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0035556 [intracellular signal transduction]
GO:0042462 [eye photoreceptor cell development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043234 [protein complex]
GO:0043434 [response to peptide hormone]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045171 [intercellular bridge]
GO:0045177 [apical part of cell]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045216 [cell-cell junction organization]
GO:0046326 [positive regulation of glucose import]
GO:0046872 [metal ion binding]
GO:0046903 [secretion]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048194 [Golgi vesicle budding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070555 [response to interleukin-1]
GO:0070830 [bicellular tight junction assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
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 596 aa
68.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.