Expression of COX18 in cancer - Summary - The Human Protein Atlas

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COX18

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COX18
Gene description	COX18 cytochrome c oxidase assembly factor
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA046772 , HPA049489
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046772	HPA049489

GENE INFORMATION
Gene name	COX18 (HGNC Symbol)
Synonyms	FLJ38991
Description	COX18 cytochrome c oxidase assembly factor (HGNC Symbol)
Entrez gene summary	This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	73052362 - 73069755
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163626 (version 83.38)
Entrez gene	285521
UniProt	Q8N8Q8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N8Q8
Antibodypedia	COX18 antibodies

PROTEIN BROWSER

COX18-001	COX18-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX18-001 ENSP00000295890 ENST00000295890	Q8N8Q8 [Direct mapping] Mitochondrial inner membrane protein COX18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008535 [respiratory chain complex IV assembly] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0031305 [integral component of mitochondrial inner membrane] GO:0051204 [protein insertion into mitochondrial membrane] GO:0051205 [protein insertion into membrane] Show all	333 aa 37.1 kDa	No	4
COX18-006 ENSP00000425261 ENST00000507544	B7ZL88 [Direct mapping] COX18 protein; Mitochondrial inner membrane protein COX18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0051205 [protein insertion into membrane] Show all	334 aa 37.1 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.