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COX18

GENERAL INFORMATION

Gene name

 COX18

Gene description

 COX18 cytochrome c oxidase assembly factor

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA046772 , HPA049489
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 COX18 (HGNC Symbol)

Synonyms

 FLJ38991

Description

 COX18 cytochrome c oxidase assembly factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 73052362 - 73069755

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163626 (version 83.38)

Entrez gene

 285521

UniProt

 Q8N8Q8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N8Q8

Antibodypedia

 COX18 antibodies

PROTEIN BROWSER
COX18-001
COX18-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COX18-001
ENSP00000295890
ENST00000295890
Q8N8Q8 [Direct mapping]
Mitochondrial inner membrane protein COX18
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008535 [respiratory chain complex IV assembly]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0031305 [integral component of mitochondrial inner membrane]
GO:0051204 [protein insertion into mitochondrial membrane]
GO:0051205 [protein insertion into membrane]
Show all
 333 aa
37.1 kDa 		No 4
COX18-006
ENSP00000425261
ENST00000507544
B7ZL88 [Direct mapping]
COX18 protein; Mitochondrial inner membrane protein COX18
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0016021 [integral component of membrane]
GO:0051205 [protein insertion into membrane]
Show all
 334 aa
37.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.