Expression of PPM1K in cancer - Summary - The Human Protein Atlas

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PPM1K

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPM1K
Gene description	Protein phosphatase, Mg2+/Mn2+ dependent, 1K
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA020066 , HPA020862 , HPA023891
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020066	HPA020862	HPA023891

GENE INFORMATION
Gene name	PPM1K (HGNC Symbol)
Synonyms	BDP, DKFZp761G058, hPTMP, PP2Ckappa, PP2Cm
Description	Protein phosphatase, Mg2+/Mn2+ dependent, 1K (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	88257620 - 88284769
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163644 (version 83.38)
Entrez gene	152926
UniProt	Q8N3J5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3J5
Antibodypedia	PPM1K antibodies

PROTEIN BROWSER

PPM1K-001	PPM1K-002	PPM1K-004	PPM1K-005	PPM1K-006	PPM1K-007	PPM1K-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPM1K-001 ENSP00000477341 ENST00000608933	Q8N3J5 [Direct mapping] Protein phosphatase 1K, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006470 [protein dephosphorylation] GO:0009083 [branched-chain amino acid catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043169 [cation binding] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	372 aa 41 kDa	No	0
PPM1K-002 ENSP00000477241 ENST00000514204	V9GYZ5 [Direct mapping] Protein phosphatase 1K (PP2C domain containing), isoform CRA_b; Protein phosphatase 1K, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0043169 [cation binding] Show all	182 aa 20.2 kDa	No	0
PPM1K-004 ENSP00000476452 ENST00000508256	V9GY69 [Direct mapping] Protein phosphatase 1K, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] Show all	153 aa 17 kDa	No	0
PPM1K-005 ENSP00000476789 ENST00000510548	V9GYI6 [Direct mapping] Protein phosphatase 1K, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	21 aa 2.6 kDa	No	0
PPM1K-006 ENSP00000477211 ENST00000509340		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		5 aa 0.5 kDa	No	0
PPM1K-007 ENSP00000477051 ENST00000505022	V9GYS8 [Direct mapping] Protein phosphatase 1K, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0043169 [cation binding] Show all	130 aa 14.5 kDa	No	0
PPM1K-009 ENSP00000295908 ENST00000295908	A0A0A0MQZ4 [Direct mapping] Protein phosphatase 1K, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0043169 [cation binding] GO:0046872 [metal ion binding] Show all	327 aa 36 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.