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PPM1K

GENERAL INFORMATION

Gene name

 PPM1K

Gene description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1K

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA020066 , HPA020862 , HPA023891
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPM1K (HGNC Symbol)

Synonyms

 BDP, DKFZp761G058, hPTMP, PP2Ckappa, PP2Cm

Description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1K (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 88257620 - 88284769

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163644 (version 83.38)

Entrez gene

 152926

UniProt

 Q8N3J5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N3J5

Antibodypedia

 PPM1K antibodies

PROTEIN BROWSER
PPM1K-001
PPM1K-002
PPM1K-004
PPM1K-005
PPM1K-006
PPM1K-007
PPM1K-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPM1K-001
ENSP00000477341
ENST00000608933
Q8N3J5 [Direct mapping]
Protein phosphatase 1K, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006470 [protein dephosphorylation]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043169 [cation binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 372 aa
41 kDa 		No 0
PPM1K-002
ENSP00000477241
ENST00000514204
V9GYZ5 [Direct mapping]
Protein phosphatase 1K (PP2C domain containing), isoform CRA_b; Protein phosphatase 1K, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
Show all
 182 aa
20.2 kDa 		No 0
PPM1K-004
ENSP00000476452
ENST00000508256
V9GY69 [Direct mapping]
Protein phosphatase 1K, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
Show all
 153 aa
17 kDa 		No 0
PPM1K-005
ENSP00000476789
ENST00000510548
V9GYI6 [Direct mapping]
Protein phosphatase 1K, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 21 aa
2.6 kDa 		No 0
PPM1K-006
ENSP00000477211
ENST00000509340
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 5 aa
0.5 kDa 		No 0
PPM1K-007
ENSP00000477051
ENST00000505022
V9GYS8 [Direct mapping]
Protein phosphatase 1K, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
Show all
 130 aa
14.5 kDa 		No 0
PPM1K-009
ENSP00000295908
ENST00000295908
A0A0A0MQZ4 [Direct mapping]
Protein phosphatase 1K, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
GO:0046872 [metal ion binding]
Show all
 327 aa
36 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.