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CXCL3

GENERAL INFORMATION

Gene name

 CXCL3

Gene description

 Chemokine (C-X-C motif) ligand 3

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enhanced (BJ hTERT+, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (adipose tissue, cervix, uterine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CXCL3 (HGNC Symbol)

Synonyms

 CINC-2b, GRO3, GROg, MIP-2b, SCYB3

Description

 Chemokine (C-X-C motif) ligand 3 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 74036589 - 74038807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163734 (version 83.38)

Entrez gene

 2921

UniProt

 P19876 (UniProt - Evidence at protein level)

neXtProt

 NX_P19876

Antibodypedia

 CXCL3 antibodies

PROTEIN BROWSER
CXCL3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCL3-001
ENSP00000296026
ENST00000296026
P19876 [Direct mapping]
C-X-C motif chemokine 3 GRO-gamma(5-73)
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
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GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0032496 [response to lipopolysaccharide]
GO:0042127 [regulation of cell proliferation]
GO:0045236 [CXCR chemokine receptor binding]
GO:0070098 [chemokine-mediated signaling pathway]
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 107 aa
11.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.