Tissue expression of CXCL3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CXCL3
Gene description	Chemokine (C-X-C motif) ligand 3
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adipose tissue, cervix, uterine)
GTEx:	Tissue enhanced (lung, stomach)
FANTOM5:	Tissue enhanced (appendix, lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, cervix, uterine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, lung)

GENE INFORMATION
Gene name	CXCL3 (HGNC Symbol)
Synonyms	CINC-2b, GRO3, GROg, MIP-2b, SCYB3
Description	Chemokine (C-X-C motif) ligand 3 (HGNC Symbol)
Entrez gene summary	This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	74036589 - 74038807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163734 (version 83.38)
Entrez gene	2921
UniProt	P19876 (UniProt - Evidence at protein level)
neXtProt	NX_P19876
Antibodypedia	CXCL3 antibodies

PROTEIN BROWSER

CXCL3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXCL3-001 ENSP00000296026 ENST00000296026	P19876 [Direct mapping] C-X-C motif chemokine 3 GRO-gamma(5-73) Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0002690 [positive regulation of leukocyte chemotaxis] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008009 [chemokine activity] GO:0030593 [neutrophil chemotaxis] GO:0032496 [response to lipopolysaccharide] GO:0042127 [regulation of cell proliferation] GO:0045236 [CXCR chemokine receptor binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	107 aa 11.3 kDa	Yes	0