Cell atlas - CXCL5 - The Human Protein Atlas

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CXCL5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CXCL5
Gene description	Chemokine (C-X-C motif) ligand 5
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (RPTEC TERT1, A549, EFO-21)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, A549, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CXCL5 (HGNC Symbol)
Synonyms	ENA-78, SCYB5
Description	Chemokine (C-X-C motif) ligand 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	73995642 - 73998779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163735 (version 83.38)
Entrez gene	6374
UniProt	P42830 (UniProt - Evidence at protein level)
neXtProt	NX_P42830
Antibodypedia	CXCL5 antibodies

PROTEIN BROWSER

CXCL5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXCL5-001 ENSP00000296027 ENST00000296027	P42830 [Direct mapping] C-X-C motif chemokine 5 ENA-78(8-78) ENA-78(9-78) Q6I9S7 [Target identity:100%; Query identity:100%] C-X-C motif chemokine Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002690 [positive regulation of leukocyte chemotaxis] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008009 [chemokine activity] GO:0008284 [positive regulation of cell proliferation] GO:0032496 [response to lipopolysaccharide] GO:0045236 [CXCR chemokine receptor binding] GO:0060326 [cell chemotaxis] GO:0070098 [chemokine-mediated signaling pathway] Show all	114 aa 12 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.