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CXCL5

GENERAL INFORMATION

Gene name

 CXCL5

Gene description

 Chemokine (C-X-C motif) ligand 5

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (lung, salivary gland)
FANTOM5:Tissue enhanced (cervix, uterine, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA065474
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, lung)

GENE INFORMATION

Gene name

 CXCL5 (HGNC Symbol)

Synonyms

 ENA-78, SCYB5

Description

 Chemokine (C-X-C motif) ligand 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 73995642 - 73998779

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163735 (version 83.38)

Entrez gene

 6374

UniProt

 P42830 (UniProt - Evidence at protein level)

neXtProt

 NX_P42830

Antibodypedia

 CXCL5 antibodies

PROTEIN BROWSER
CXCL5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCL5-001
ENSP00000296027
ENST00000296027
P42830 [Direct mapping]
C-X-C motif chemokine 5 ENA-78(8-78) ENA-78(9-78)
Q6I9S7 [Target identity:100%; Query identity:100%]
C-X-C motif chemokine
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
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GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0045236 [CXCR chemokine receptor binding]
GO:0060326 [cell chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
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 114 aa
12 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.