Expression of CDCP1 in cancer - Summary

GENERAL INFORMATION
Gene name	CDCP1
Gene description	CUB domain containing protein 1
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, PC-3, RPTEC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in stratified epithelia, gastrointestinal tract, male and female genitalia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA010978 , HPA010979 , CAB025637
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Lung cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA010978	HPA010979	CAB025637

GENE INFORMATION
Gene name	CDCP1 (HGNC Symbol)
Synonyms	CD318, SIMA135
Description	CUB domain containing protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	45082278 - 45146422
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163814 (version 83.38)
Entrez gene	64866
UniProt	Q9H5V8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H5V8
Antibodypedia	CDCP1 antibodies

PROTEIN BROWSER

CDCP1-001	CDCP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDCP1-001 ENSP00000296129 ENST00000296129	Q9H5V8 [Direct mapping] CUB domain-containing protein 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	836 aa 92.9 kDa	Yes	1
CDCP1-002 ENSP00000399342 ENST00000425231	Q9H5V8 [Direct mapping] CUB domain-containing protein 1 Show all	CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	343 aa 37.8 kDa	Yes	0