Expression of CLEC3B in cancer - Summary - The Human Protein Atlas

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CLEC3B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLEC3B
Gene description	C-type lectin domain family 3, member B
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (ASC TERT1, U-2197)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Plasma positivity in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA034794 , CAB002582
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable), head and neck cancer (favourable) and pancreatic cancer (favourable).
Liver cancer p<0.001 Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034794	CAB002582

GENE INFORMATION
Gene name	CLEC3B (HGNC Symbol)
Synonyms	TN, TNA
Description	C-type lectin domain family 3, member B (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	45001548 - 45036071
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163815 (version 83.38)
Entrez gene	7123
UniProt	P05452 (UniProt - Evidence at protein level)
neXtProt	NX_P05452
Antibodypedia	CLEC3B antibodies

PROTEIN BROWSER

CLEC3B-001	CLEC3B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC3B-001 ENSP00000296130 ENST00000296130	P05452 [Direct mapping] Tetranectin A0A024R2Q7 [Target identity:100%; Query identity:100%] C-type lectin domain family 3, member B, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0001652 [granular component] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0008201 [heparin binding] GO:0010756 [positive regulation of plasminogen activation] GO:0030246 [carbohydrate binding] GO:0030282 [bone mineralization] GO:0031012 [extracellular matrix] GO:0036143 [kringle domain binding] GO:0070062 [extracellular exosome] GO:0071310 [cellular response to organic substance] GO:0071560 [cellular response to transforming growth factor beta stimulus] Show all	202 aa 22.5 kDa	Yes	0
CLEC3B-002 ENSP00000396013 ENST00000428034	E9PHK0 [Direct mapping] Tetranectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.