Expression of LRRC2 in cancer - Summary - The Human Protein Atlas

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LRRC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC2
Gene description	Leucine rich repeat containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enhanced (HEL, LHCN-M2, TIME)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with varying intensities.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA039138 , HPA040096
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039138	HPA040096

GENE INFORMATION
Gene name	LRRC2
Synonyms
Description	Leucine rich repeat containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	46515423 - 46580099
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163827 (version 83.38)
Entrez gene	79442
UniProt	Q9BYS8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BYS8
Antibodypedia	LRRC2 antibodies

PROTEIN BROWSER

LRRC2-001	LRRC2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC2-001 ENSP00000379241 ENST00000395905	Q9BYS8 [Direct mapping] Leucine-rich repeat-containing protein 2 A0A024R2R5 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 2, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	371 aa 42.9 kDa	No	0
LRRC2-002 ENSP00000296144 ENST00000296144	Q9BYS8 [Direct mapping] Leucine-rich repeat-containing protein 2 A0A024R2R5 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 2, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	371 aa 42.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.