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LRRC2

GENERAL INFORMATION

Gene name

 LRRC2

Gene description

 Leucine rich repeat containing 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (heart muscle, skeletal muscle, thyroid gland)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Tissue enhanced (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with varying intensities.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA039138 , HPA040096
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, skeletal muscle)

GENE INFORMATION

Gene name

 LRRC2

Synonyms

Description

 Leucine rich repeat containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46515423 - 46580099

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163827 (version 83.38)

Entrez gene

 79442

UniProt

 Q9BYS8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BYS8

Antibodypedia

 LRRC2 antibodies

PROTEIN BROWSER
LRRC2-001
LRRC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRRC2-001
ENSP00000379241
ENST00000395905
Q9BYS8 [Direct mapping]
Leucine-rich repeat-containing protein 2
A0A024R2R5 [Target identity:100%; Query identity:100%]
Leucine rich repeat containing 2, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
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 371 aa
42.9 kDa 		No 0
LRRC2-002
ENSP00000296144
ENST00000296144
Q9BYS8 [Direct mapping]
Leucine-rich repeat-containing protein 2
A0A024R2R5 [Target identity:100%; Query identity:100%]
Leucine rich repeat containing 2, isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 371 aa
42.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.