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Moderate to strong cytoplasmic immunoreactivity was mainly observed in breast cancers, thyroid cancers, lymphomas and carcinoids. A majority of the remaining cancers were in general weakly stained or negative.
A majority of cancer cells showed moderate to strong cytoplasmic and membranous positivity. Malignant lymphomas, ovarian and thyroid cancers predominantly showed strong staining. Testicular cancers were generally negative.
GENE INFORMATION
Gene name
PRKCD
Synonyms
Description
Protein kinase C, delta (HGNC Symbol)
Entrez gene summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004699 [calcium-independent protein kinase C activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008047 [enzyme activator activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010467 [gene expression] GO:0010469 [regulation of receptor activity] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0016064 [immunoglobulin mediated immune response] GO:0016363 [nuclear matrix] GO:0016572 [histone phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0023021 [termination of signal transduction] GO:0030168 [platelet activation] GO:0030837 [negative regulation of actin filament polymerization] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032091 [negative regulation of protein binding] GO:0032613 [interleukin-10 production] GO:0032615 [interleukin-12 production] GO:0032930 [positive regulation of superoxide anion generation] GO:0032956 [regulation of actin cytoskeleton organization] GO:0034351 [negative regulation of glial cell apoptotic process] GO:0035307 [positive regulation of protein dephosphorylation] GO:0035556 [intracellular signal transduction] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042100 [B cell proliferation] GO:0042119 [neutrophil activation] GO:0042307 [positive regulation of protein import into nucleus] GO:0042742 [defense response to bacterium] GO:0043407 [negative regulation of MAP kinase activity] GO:0043488 [regulation of mRNA stability] GO:0043560 [insulin receptor substrate binding] GO:0045087 [innate immune response] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050728 [negative regulation of inflammatory response] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051490 [negative regulation of filopodium assembly] GO:0060326 [cell chemotaxis] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0071447 [cellular response to hydroperoxide] GO:0090331 [negative regulation of platelet aggregation] GO:0090398 [cellular senescence] GO:1900163 [positive regulation of phospholipid scramblase activity] GO:2000304 [positive regulation of ceramide biosynthetic process] GO:2000753 [positive regulation of glucosylceramide catabolic process] GO:2000755 [positive regulation of sphingomyelin catabolic process] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001235 [positive regulation of apoptotic signaling pathway]
Q05655 [Direct mapping] Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit A0A024R328 [Target identity:100%; Query identity:100%] Protein kinase C delta type
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004699 [calcium-independent protein kinase C activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008047 [enzyme activator activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010467 [gene expression] GO:0010469 [regulation of receptor activity] GO:0012501 [programmed cell death] GO:0016572 [histone phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0023021 [termination of signal transduction] GO:0030168 [platelet activation] GO:0030837 [negative regulation of actin filament polymerization] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032091 [negative regulation of protein binding] GO:0032930 [positive regulation of superoxide anion generation] GO:0032956 [regulation of actin cytoskeleton organization] GO:0034351 [negative regulation of glial cell apoptotic process] GO:0035307 [positive regulation of protein dephosphorylation] GO:0035556 [intracellular signal transduction] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042119 [neutrophil activation] GO:0042307 [positive regulation of protein import into nucleus] GO:0042742 [defense response to bacterium] GO:0043407 [negative regulation of MAP kinase activity] GO:0043488 [regulation of mRNA stability] GO:0043560 [insulin receptor substrate binding] GO:0045087 [innate immune response] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050728 [negative regulation of inflammatory response] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051490 [negative regulation of filopodium assembly] GO:0060326 [cell chemotaxis] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0071447 [cellular response to hydroperoxide] GO:0090331 [negative regulation of platelet aggregation] GO:0090398 [cellular senescence] GO:1900163 [positive regulation of phospholipid scramblase activity] GO:2000304 [positive regulation of ceramide biosynthetic process] GO:2000753 [positive regulation of glucosylceramide catabolic process] GO:2000755 [positive regulation of sphingomyelin catabolic process] GO:2001022 [positive regulation of response to DNA damage stimulus]