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H2AFZ

GENERAL INFORMATION

Gene name

 H2AFZ

Gene description

 H2A histone family, member Z

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA057236 , CAB022549
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057236
CAB022549

GENE INFORMATION

Gene name

 H2AFZ (HGNC Symbol)

Synonyms

 H2A.Z, H2AZ

Description

 H2A histone family, member Z (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99948086 - 99950388

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164032 (version 83.38)

Entrez gene

 3015

UniProt

 P0C0S5 (UniProt - Evidence at protein level)

neXtProt

 NX_P0C0S5

Antibodypedia

 H2AFZ antibodies

PROTEIN BROWSER
H2AFZ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H2AFZ-001
ENSP00000296417
ENST00000296417
P0C0S5 [Direct mapping]
Histone H2A.Z
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
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GO:0000786 [nucleosome]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005719 [nuclear euchromatin]
GO:0005720 [nuclear heterochromatin]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0031490 [chromatin DNA binding]
GO:0031492 [nucleosomal DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
GO:0071392 [cellular response to estradiol stimulus]
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 128 aa
13.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.