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BDH2

GENERAL INFORMATION

Gene name

 BDH2

Gene description

 3-hydroxybutyrate dehydrogenase, type 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036028 , HPA036029
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable), endometrial cancer (favourable) and thyroid cancer (favourable).
Renal cancer p<0.001
Lung cancer p<0.001
Endometrial cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036028
HPA036029

GENE INFORMATION

Gene name

 BDH2 (HGNC Symbol)

Synonyms

 DHRS6, FLJ13261, PRO20933, SDR15C1, UCPA-OR, UNQ6308

Description

 3-hydroxybutyrate dehydrogenase, type 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q24

Chromosome location (bp)

 103079435 - 103099883

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164039 (version 83.38)

Entrez gene

 56898

UniProt

 Q9BUT1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUT1

Antibodypedia

 BDH2 antibodies

PROTEIN BROWSER
BDH2-001
BDH2-006
BDH2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BDH2-001
ENSP00000296424
ENST00000296424
Q9BUT1 [Direct mapping]
3-hydroxybutyrate dehydrogenase type 2
A0A024RDG9 [Target identity:100%; Query identity:100%]
3-hydroxybutyrate dehydrogenase, type 2, isoform CRA_b
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003858 [3-hydroxybutyrate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006635 [fatty acid beta-oxidation]
GO:0016491 [oxidoreductase activity]
GO:0016628 [oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor]
GO:0019290 [siderophore biosynthetic process]
GO:0030855 [epithelial cell differentiation]
GO:0042168 [heme metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046950 [cellular ketone body metabolic process]
GO:0046951 [ketone body biosynthetic process]
GO:0051287 [NAD binding]
GO:0055072 [iron ion homeostasis]
GO:0070062 [extracellular exosome]
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 245 aa
26.7 kDa 		No 0
BDH2-006
ENSP00000422891
ENST00000509245
D6R9U8 [Direct mapping]
3-hydroxybutyrate dehydrogenase type 2
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0008667 [2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0019290 [siderophore biosynthetic process]
GO:0055114 [oxidation-reduction process]
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 116 aa
12.9 kDa 		No 0
BDH2-007
ENSP00000427442
ENST00000504285
D6RIR6 [Direct mapping]
3-hydroxybutyrate dehydrogenase type 2
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 130 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.