Expression of CAMP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CAMP
Gene description	Cathelicidin antimicrobial peptide
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Group enriched (Daudi, hTCEpi, U-698)
HPA (normal tissue):	Group enriched (bone marrow, epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of immune cells in several tissues, most abundant in bone marrow and spleen.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA029874 , CAB015949 , CAB016522
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029874	CAB015949	CAB016522

GENE INFORMATION
Gene name	CAMP (HGNC Symbol)
Synonyms	CAP18, FALL-39, FALL39, LL37
Description	Cathelicidin antimicrobial peptide (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48223347 - 48225491
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164047 (version 83.38)
Entrez gene	820
UniProt
neXtProt
Antibodypedia	CAMP antibodies

PROTEIN BROWSER

CAMP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAMP-001 ENSP00000296435 ENST00000296435	J3KNB4 [Direct mapping] Cathelicidin antimicrobial peptide Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006952 [defense response] GO:0008284 [positive regulation of cell proliferation] GO:0042742 [defense response to bacterium] GO:0042995 [cell projection] GO:0045766 [positive regulation of angiogenesis] GO:0050829 [defense response to Gram-negative bacterium] GO:0050830 [defense response to Gram-positive bacterium] GO:0071222 [cellular response to lipopolysaccharide] GO:0071224 [cellular response to peptidoglycan] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] Show all	173 aa 19.6 kDa	Yes	0