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CAMP

GENERAL INFORMATION

Gene name

 CAMP

Gene description

 Cathelicidin antimicrobial peptide

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (bone marrow, epididymis)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in subsets of immune cells in several tissues, most abundant in bone marrow and spleen.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA029874 , CAB015949 , CAB016522
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (bone marrow, epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION

Gene name

 CAMP (HGNC Symbol)

Synonyms

 CAP18, FALL-39, FALL39, LL37

Description

 Cathelicidin antimicrobial peptide (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48223347 - 48225491

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164047 (version 83.38)

Entrez gene

 820

UniProt

neXtProt

Antibodypedia

 CAMP antibodies

PROTEIN BROWSER
CAMP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAMP-001
ENSP00000296435
ENST00000296435
J3KNB4 [Direct mapping]
Cathelicidin antimicrobial peptide
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006952 [defense response]
GO:0008284 [positive regulation of cell proliferation]
GO:0042742 [defense response to bacterium]
GO:0042995 [cell projection]
GO:0045766 [positive regulation of angiogenesis]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071224 [cellular response to peptidoglycan]
GO:0071347 [cellular response to interleukin-1]
GO:0071354 [cellular response to interleukin-6]
GO:0071356 [cellular response to tumor necrosis factor]
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 173 aa
19.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.