Expression of FBXW12 in cancer - Summary - The Human Protein Atlas

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FBXW12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FBXW12
Gene description	F-box and WD repeat domain containing 12
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (pancreas, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA037491 , HPA037492
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037491	HPA037492

GENE INFORMATION
Gene name	FBXW12 (HGNC Symbol)
Synonyms	Fbw12, FBXO35
Description	F-box and WD repeat domain containing 12 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48372219 - 48401259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164049 (version 83.38)
Entrez gene	285231
UniProt	Q6X9E4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6X9E4
Antibodypedia	FBXW12 antibodies

PROTEIN BROWSER

FBXW12-001	FBXW12-002	FBXW12-003	FBXW12-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXW12-001 ENSP00000296438 ENST00000296438	Q6X9E4 [Direct mapping] F-box/WD repeat-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	464 aa 53.1 kDa	No	1
FBXW12-002 ENSP00000413866 ENST00000436231	C9JK86 [Direct mapping] F-box/WD repeat-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] Show all	307 aa 34.5 kDa	No	1
FBXW12-003 ENSP00000406139 ENST00000445170	Q6X9E4 [Direct mapping] F-box/WD repeat-containing protein 12 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] Show all	445 aa 50.8 kDa	No	0
FBXW12-004 ENSP00000414683 ENST00000415155	Q6X9E4 [Direct mapping] F-box/WD repeat-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	394 aa 45 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.