Expression of MST1R in cancer - Summary - The Human Protein Atlas

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MST1R

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MST1R
Gene description	Macrophage stimulating 1 receptor
Protein class	CD markers Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, hTCEpi, RT4)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA007657 , HPA008180 , CAB008972
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007657	HPA008180	CAB008972

GENE INFORMATION
Gene name	MST1R (HGNC Symbol)
Synonyms	CD136, CDw136, PTK8, RON
Description	Macrophage stimulating 1 receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49887002 - 49903873
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164078 (version 83.38)
Entrez gene	4486
UniProt	Q04912 (UniProt - Evidence at protein level)
neXtProt	NX_Q04912
Antibodypedia	MST1R antibodies

PROTEIN BROWSER

MST1R-001	MST1R-002	MST1R-010	MST1R-011	MST1R-201	MST1R-202	MST1R-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MST1R-001 ENSP00000296474 ENST00000296474	Q04912 [Direct mapping] Macrophage-stimulating protein receptor Macrophage-stimulating protein receptor alpha chain Macrophage-stimulating protein receptor beta chain Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005011 [macrophage colony-stimulating factor receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005773 [vacuole] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006928 [movement of cell or subcellular component] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007338 [single fertilization] GO:0008284 [positive regulation of cell proliferation] GO:0009615 [response to virus] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0038145 [macrophage colony-stimulating factor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0045087 [innate immune response] GO:0051897 [positive regulation of protein kinase B signaling] Show all	1400 aa 152.2 kDa	Yes	1
MST1R-002 ENSP00000341325 ENST00000344206	Q04912 [Direct mapping] Macrophage-stimulating protein receptor Macrophage-stimulating protein receptor alpha chain Macrophage-stimulating protein receptor beta chain Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005011 [macrophage colony-stimulating factor receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006928 [movement of cell or subcellular component] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007338 [single fertilization] GO:0008284 [positive regulation of cell proliferation] GO:0009615 [response to virus] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0038145 [macrophage colony-stimulating factor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0045087 [innate immune response] GO:0051897 [positive regulation of protein kinase B signaling] Show all	1351 aa 147.2 kDa	Yes	1
MST1R-010 ENSP00000414792 ENST00000440292	H7C3Z8 [Direct mapping] Macrophage-stimulating protein receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	270 aa 30 kDa	No	0
MST1R-011 ENSP00000393294 ENST00000434765	H7C074 [Direct mapping] Macrophage-stimulating protein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	285 aa 32.3 kDa	No	1
MST1R-201 ENSP00000481084 ENST00000612032	H2E272 [Direct mapping] MST1R variant RON30; Macrophage-stimulating protein receptor Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	254 aa 29.4 kDa	No	0
MST1R-202 ENSP00000482827 ENST00000613534	A0A087WZQ8 [Direct mapping] Macrophage-stimulating protein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	574 aa 62.3 kDa	Yes	1
MST1R-203 ENSP00000482642 ENST00000621387	A0A087WZG2 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	1294 aa 140.7 kDa	Yes	1

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