Expression of ETNPPL in cancer - Summary - The Human Protein Atlas

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ETNPPL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ETNPPL
Gene description	Ethanolamine-phosphate phospho-lyase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, liver cancer)
HPA (cell line):	Cell line enhanced (HeLa, Hep G2, NTERA-2)
HPA (normal tissue):	Group enriched (cerebral cortex, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in several tissues including CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA044546
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044546

GENE INFORMATION
Gene name	ETNPPL (HGNC Symbol)
Synonyms	AGXT2L1
Description	Ethanolamine-phosphate phospho-lyase (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q25
Chromosome location (bp)	108742040 - 108763054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164089 (version 83.38)
Entrez gene	64850
UniProt	Q8TBG4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBG4
Antibodypedia	ETNPPL antibodies

PROTEIN BROWSER

ETNPPL-001	ETNPPL-002	ETNPPL-003	ETNPPL-004	ETNPPL-006	ETNPPL-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ETNPPL-001 ENSP00000423240 ENST00000510706	E7ENR6 [Direct mapping] Ethanolamine-phosphate phospho-lyase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	459 aa 51 kDa	No	0
ETNPPL-002 ENSP00000296486 ENST00000296486	Q8TBG4 [Direct mapping] Ethanolamine-phosphate phospho-lyase Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005575 [cellular_component] GO:0005759 [mitochondrial matrix] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0050459 [ethanolamine-phosphate phospho-lyase activity] Show all	499 aa 55.7 kDa	No	0
ETNPPL-003 ENSP00000392269 ENST00000411864	Q8TBG4 [Direct mapping] Ethanolamine-phosphate phospho-lyase Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005575 [cellular_component] GO:0005759 [mitochondrial matrix] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0050459 [ethanolamine-phosphate phospho-lyase activity] Show all	493 aa 55 kDa	No	0
ETNPPL-004 ENSP00000427065 ENST00000512646	Q8TBG4 [Direct mapping] Ethanolamine-phosphate phospho-lyase Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005575 [cellular_component] GO:0005759 [mitochondrial matrix] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0050459 [ethanolamine-phosphate phospho-lyase activity] Show all	441 aa 48.9 kDa	No	0
ETNPPL-006 ENSP00000426525 ENST00000510723	D6RFL9 [Direct mapping] Ethanolamine-phosphate phospho-lyase Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	70 aa 7.8 kDa	No	0
ETNPPL-007 ENSP00000421217 ENST00000512320	D6RGG2 [Direct mapping] Ethanolamine-phosphate phospho-lyase Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0030170 [pyridoxal phosphate binding] Show all	60 aa 6.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.