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ETNPPL

GENERAL INFORMATION

Gene name

 ETNPPL

Gene description

 Ethanolamine-phosphate phospho-lyase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, liver)
GTEx:Tissue enhanced (caudate, cerebral cortex, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, liver)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in several tissues including CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA044546
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebral cortex, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, liver)

GENE INFORMATION

Gene name

 ETNPPL (HGNC Symbol)

Synonyms

 AGXT2L1

Description

 Ethanolamine-phosphate phospho-lyase (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 108742040 - 108763054

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164089 (version 83.38)

Entrez gene

 64850

UniProt

 Q8TBG4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TBG4

Antibodypedia

 ETNPPL antibodies

PROTEIN BROWSER
ETNPPL-001
ETNPPL-002
ETNPPL-003
ETNPPL-004
ETNPPL-006
ETNPPL-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ETNPPL-001
ENSP00000423240
ENST00000510706
E7ENR6 [Direct mapping]
Ethanolamine-phosphate phospho-lyase
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0008483 [transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
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 459 aa
51 kDa 		No 0
ETNPPL-002
ENSP00000296486
ENST00000296486
Q8TBG4 [Direct mapping]
Ethanolamine-phosphate phospho-lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005575 [cellular_component]
GO:0005759 [mitochondrial matrix]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0008483 [transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0050459 [ethanolamine-phosphate phospho-lyase activity]
Show all
 499 aa
55.7 kDa 		No 0
ETNPPL-003
ENSP00000392269
ENST00000411864
Q8TBG4 [Direct mapping]
Ethanolamine-phosphate phospho-lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005575 [cellular_component]
GO:0005759 [mitochondrial matrix]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0008483 [transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0050459 [ethanolamine-phosphate phospho-lyase activity]
Show all
 493 aa
55 kDa 		No 0
ETNPPL-004
ENSP00000427065
ENST00000512646
Q8TBG4 [Direct mapping]
Ethanolamine-phosphate phospho-lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005575 [cellular_component]
GO:0005759 [mitochondrial matrix]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0008483 [transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0050459 [ethanolamine-phosphate phospho-lyase activity]
Show all
 441 aa
48.9 kDa 		No 0
ETNPPL-006
ENSP00000426525
ENST00000510723
D6RFL9 [Direct mapping]
Ethanolamine-phosphate phospho-lyase
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0008483 [transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
Show all
 70 aa
7.8 kDa 		No 0
ETNPPL-007
ENSP00000421217
ENST00000512320
D6RGG2 [Direct mapping]
Ethanolamine-phosphate phospho-lyase
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0008483 [transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
Show all
 60 aa
6.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.