Expression of NDST3 in cancer - Summary - The Human Protein Atlas

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NDST3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NDST3
Gene description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA056189
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056189

GENE INFORMATION
Gene name	NDST3 (HGNC Symbol)
Synonyms	HSST3
Description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]
Chromosome	4
Cytoband	q26
Chromosome location (bp)	118033618 - 118258648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164100 (version 83.38)
Entrez gene	9348
UniProt	O95803 (UniProt - Evidence at transcript level)
neXtProt	NX_O95803
Antibodypedia	NDST3 antibodies

PROTEIN BROWSER

NDST3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDST3-001 ENSP00000296499 ENST00000296499	O95803 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 Heparan sulfate N-deacetylase 3 Heparan sulfate N-sulfotransferase 3 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0008146 [sulfotransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0019213 [deacetylase activity] GO:0030210 [heparin biosynthetic process] Show all	873 aa 100.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.