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NDST3

GENERAL INFORMATION

Gene name

 NDST3

Gene description

 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, spleen)
GTEx:Tissue enhanced (caudate, cerebellum, cerebral cortex)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Uncertain based on 1 antibody.
HPA056189
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, spleen)

GENE INFORMATION

Gene name

 NDST3 (HGNC Symbol)

Synonyms

 HSST3

Description

 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]

Chromosome

 4

Cytoband

 q26

Chromosome location (bp)

 118033618 - 118258648

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164100 (version 83.38)

Entrez gene

 9348

UniProt

 O95803 (UniProt - Evidence at transcript level)

neXtProt

 NX_O95803

Antibodypedia

 NDST3 antibodies

PROTEIN BROWSER
NDST3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NDST3-001
ENSP00000296499
ENST00000296499
O95803 [Direct mapping]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 Heparan sulfate N-deacetylase 3 Heparan sulfate N-sulfotransferase 3
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane]
GO:0008146 [sulfotransferase activity]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0019213 [deacetylase activity]
GO:0030210 [heparin biosynthetic process]
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 873 aa
100.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.