Cell atlas - ICE1 - The Human Protein Atlas

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ICE1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ICE1
Gene description	Interactor of little elongation complex ELL subunit 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061934
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (supported), Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061934	HeLa	Nucleoplasm
	HPA061934	HeLa	Nuclear bodies
	HPA061934	SiHa	Nucleoplasm
	HPA061934	SiHa	Nuclear bodies

GENE INFORMATION
Gene name	ICE1 (HGNC Symbol)
Synonyms	KIAA0947
Description	Interactor of little elongation complex ELL subunit 1 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.32
Chromosome location (bp)	5420664 - 5490234
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164151 (version 83.38)
Entrez gene	23379
UniProt	Q9Y2F5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2F5
Antibodypedia	ICE1 antibodies

PROTEIN BROWSER

ICE1-001	ICE1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ICE1-001 ENSP00000296564 ENST00000296564	Q9Y2F5 [Direct mapping] Little elongation complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008023 [transcription elongation factor complex] GO:0015030 [Cajal body] GO:0031334 [positive regulation of protein complex assembly] GO:0035327 [transcriptionally active chromatin] GO:0035363 [histone locus body] GO:0042795 [snRNA transcription from RNA polymerase II promoter] GO:0042796 [snRNA transcription from RNA polymerase III promoter] GO:0042803 [protein homodimerization activity] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0090316 [positive regulation of intracellular protein transport] Show all	2266 aa 247.9 kDa	No	0
ICE1-005 ENSP00000485617 ENST00000512608	A0A096LPH9 [Direct mapping] Little elongation complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 17.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.