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AGGF1

GENERAL INFORMATION

Gene name

 AGGF1

Gene description

 Angiogenic factor with G patch and FHA domains 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA043500
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043500

GENE INFORMATION

Gene name

 AGGF1 (HGNC Symbol)

Synonyms

 FLJ10283, GPATC7, GPATCH7, HSU84971, VG5Q

Description

 Angiogenic factor with G patch and FHA domains 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]

Chromosome

 5

Cytoband

 q13.3

Chromosome location (bp)

 77029251 - 77065234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164252 (version 83.38)

Entrez gene

 55109

UniProt

 Q8N302 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N302

Antibodypedia

 AGGF1 antibodies

PROTEIN BROWSER
AGGF1-001
AGGF1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGGF1-001
ENSP00000316109
ENST00000312916
Q8N302 [Direct mapping]
Angiogenic factor with G patch and FHA domains 1
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0001570 [vasculogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0007155 [cell adhesion]
GO:0045766 [positive regulation of angiogenesis]
GO:0048471 [perinuclear region of cytoplasm]
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 714 aa
81 kDa 		No 0
AGGF1-002
ENSP00000424733
ENST00000506806
Q8N302 [Direct mapping]
Angiogenic factor with G patch and FHA domains 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001570 [vasculogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0007155 [cell adhesion]
GO:0045766 [positive regulation of angiogenesis]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 176 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.