Expression of HTR4 in cancer - Summary - The Human Protein Atlas

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HTR4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HTR4
Gene description	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in intestine and CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA040591
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040591

GENE INFORMATION
Gene name	HTR4 (HGNC Symbol)
Synonyms	5-HT4
Description	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled (HGNC Symbol)
Entrez gene summary	This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	148451032 - 148677235
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164270 (version 83.38)
Entrez gene	3360
UniProt	Q13639 (UniProt - Evidence at protein level)
neXtProt	NX_Q13639
Antibodypedia	HTR4 antibodies

PROTEIN BROWSER

HTR4-001	HTR4-002	HTR4-006	HTR4-007	HTR4-008	HTR4-009	HTR4-011	HTR4-201	HTR4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTR4-001 ENSP00000367120 ENST00000377888	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	388 aa 43.8 kDa	No	7
HTR4-002 ENSP00000429634 ENST00000520086	E5RHV8 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	Predicted intracellular proteins Show all	GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] Show all	87 aa 10.1 kDa	No	0
HTR4-006 ENSP00000430979 ENST00000521735	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	378 aa 42.7 kDa	No	7
HTR4-007 ENSP00000427913 ENST00000520514	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	411 aa 46.9 kDa	No	7
HTR4-008 ENSP00000353915 ENST00000360693	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	428 aa 48.3 kDa	No	7
HTR4-009 ENSP00000428320 ENST00000521530	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	387 aa 44.1 kDa	No	7
HTR4-011 ENSP00000435904 ENST00000517929	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	360 aa 40.9 kDa	No	7
HTR4-201 ENSP00000355037 ENST00000362016	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	428 aa 48.3 kDa	No	7
HTR4-202 ENSP00000485747 ENST00000631296	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	388 aa 43.8 kDa	No	7

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