Tissue expression of HTR4 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HTR4

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HTR4
Gene description	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (duodenum, small intestine)
GTEx:	Tissue enhanced (small intestine)
FANTOM5:	Group enriched (caudate, colon, hippocampus, pituitary gland, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in intestine and CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA040591
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (duodenum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, colon, hippocampus, pituitary gland, small intestine)

GENE INFORMATION
Gene name	HTR4 (HGNC Symbol)
Synonyms	5-HT4
Description	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled (HGNC Symbol)
Entrez gene summary	This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	148451032 - 148677235
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164270 (version 83.38)
Entrez gene	3360
UniProt	Q13639 (UniProt - Evidence at protein level)
neXtProt	NX_Q13639
Antibodypedia	HTR4 antibodies

PROTEIN BROWSER

HTR4-001	HTR4-002	HTR4-006	HTR4-007	HTR4-008	HTR4-009	HTR4-011	HTR4-201	HTR4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTR4-001 ENSP00000367120 ENST00000377888	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	388 aa 43.8 kDa	No	7
HTR4-002 ENSP00000429634 ENST00000520086	E5RHV8 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	Predicted intracellular proteins Show all	GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] Show all	87 aa 10.1 kDa	No	0
HTR4-006 ENSP00000430979 ENST00000521735	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	378 aa 42.7 kDa	No	7
HTR4-007 ENSP00000427913 ENST00000520514	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	411 aa 46.9 kDa	No	7
HTR4-008 ENSP00000353915 ENST00000360693	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	428 aa 48.3 kDa	No	7
HTR4-009 ENSP00000428320 ENST00000521530	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	387 aa 44.1 kDa	No	7
HTR4-011 ENSP00000435904 ENST00000517929	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	360 aa 40.9 kDa	No	7
HTR4-201 ENSP00000355037 ENST00000362016	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	428 aa 48.3 kDa	No	7
HTR4-202 ENSP00000485747 ENST00000631296	Q13639 [Direct mapping] 5-hydroxytryptamine receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007606 [sensory perception of chemical stimulus] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032098 [regulation of appetite] Show all	388 aa 43.8 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.