Expression of ARSK in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ARSK
Gene description	Arylsulfatase family, member K
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues. Additional membranous expression in some tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA042384
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042384

GENE INFORMATION
Gene name	ARSK (HGNC Symbol)
Synonyms	DKFZp313G1735, TSULF
Description	Arylsulfatase family, member K (HGNC Symbol)
Entrez gene summary	Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q15
Chromosome location (bp)	95555074 - 95605064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164291 (version 83.38)
Entrez gene	153642
UniProt	Q6UWY0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWY0
Antibodypedia	ARSK antibodies

PROTEIN BROWSER

ARSK-001	ARSK-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARSK-001 ENSP00000369346 ENST00000380009	Q6UWY0 [Direct mapping] Arylsulfatase K Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	536 aa 61.4 kDa	Yes	0
ARSK-003 ENSP00000422126 ENST00000504763	D6R9F9 [Direct mapping] Arylsulfatase K Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 4.8 kDa	Yes	0