Fields »
ABOUT
HELP
BLOG
ARSK

GENERAL INFORMATION

Gene name

 ARSK

Gene description

 Arylsulfatase family, member K

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues. Additional membranous expression in some tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA042384
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARSK (HGNC Symbol)

Synonyms

 DKFZp313G1735, TSULF

Description

 Arylsulfatase family, member K (HGNC Symbol)

Entrez gene summary

 Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 q15

Chromosome location (bp)

 95555074 - 95605064

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164291 (version 83.38)

Entrez gene

 153642

UniProt

 Q6UWY0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6UWY0

Antibodypedia

 ARSK antibodies

PROTEIN BROWSER
ARSK-001
ARSK-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARSK-001
ENSP00000369346
ENST00000380009
Q6UWY0 [Direct mapping]
Arylsulfatase K
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004065 [arylsulfatase activity]
GO:0005576 [extracellular region]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008152 [metabolic process]
GO:0008484 [sulfuric ester hydrolase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 536 aa
61.4 kDa 		Yes 0
ARSK-003
ENSP00000422126
ENST00000504763
D6R9F9 [Direct mapping]
Arylsulfatase K
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 46 aa
4.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.